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生物通
10 个月
早期生长反应基因1(Egr-1)通过调控Foxp3促进调节性T细胞分化改善 ...
本研究针对自身免疫性疾病中调节性T细胞(T reg )功能失调的核心问题,揭示了早期生长反应基因1(Egr-1)通过Raf-Erk信号通路激活Foxp3表达,促进T reg 分化并缓解实验性自身免疫性脑脊髓炎(EAE)的分子机制。研究人员发现Egr-1激动剂Calycosin(CAL)可显著减轻EAE ...
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