Germline and somatic sequence variants in non-coding regions can play an important role in cancer. Many different modes of action of non-coding variants are known. For example, point mutations and ...

The identification of evolutionarily constrained sequences is an unbiased approach for finding functional sequences in genomes. However, their identification is strongly affected by upstream analyses.

Two examples of the same molecule represented in sequence, image and graph formats are provided for direct comparison. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...