Figure 1: smFRET analysis of pre-mRNA splicing using the HMM. We present here a method, Single Molecule Cluster Analysis (SiMCAn), that utilizes hierarchical clustering as a means to group, sort and ...

Because liver cancer is particularly diverse, genetically, and prone to relapse, identifying biomarkers that can predict disease progression is a critical goal in the fight against it. Researchers at ...

Cold Spring Harbor, NY – A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with ...

SAN DIEGO, CA - Genes are like instructions, but with options for building more than one thing. Daniel Larson, senior investigator at the National Cancer Institute, studies this gene "splicing" ...

Researchers have developed a new way of making animal models for a broad class of human genetic diseases -- those with pathology caused by errors in the splicing of RNA messages copied from genes. The ...

Researchers developed molecules, called splice-switching oligonucleotides (SSOs) that bind to the RNA molecules encoding a protein known as REST. In neuroendocrine tumors, these RNAs are incorrectly ...